Pub. Date : 2014 Nov
PMID : 25128742
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that SIRT1 essentially mediates hydrogen peroxide (H2O2)-induced cytotoxicity in human umbilical vein endothelial cell (HUVEC). | Hydrogen Peroxide | sirtuin 1 | Homo sapiens |
| 2 | Here, we show that SIRT1 essentially mediates hydrogen peroxide (H2O2)-induced cytotoxicity in human umbilical vein endothelial cell (HUVEC). | Hydrogen Peroxide | sirtuin 1 | Homo sapiens |
| 3 | In HUVECs, SIRT1 protein expression was significantly increased in a dose-dependent manner after H2O2 treatment, whereas the acetylation levels of the NF-kappaB p65 subunit and p53 were decreased. | Hydrogen Peroxide | sirtuin 1 | Homo sapiens |
| 4 | EX527 (a specific SIRT1 inhibitor) conferred protection to the HUVECs against H2O2, as indicated by an improved cell viability, adhesion, an enhanced migratory ability, a decreased apoptotic index, decreased reactive oxygen species (ROS) production and reductions in several biochemical parameters. | Hydrogen Peroxide | sirtuin 1 | Homo sapiens |
| 5 | Immunofluorescence and Western blot analyses demonstrated that H2O2 treatment up-regulated SIRT1, phosphorylated-JNK (p-JNK), p-p38MAPK, and p-ERK expression. | Hydrogen Peroxide | sirtuin 1 | Homo sapiens |