Title : Failure of preactivated human blood platelets to restore defective thromboxane synthesis despite prolonged incubation in plasma.

Pub. Date : 1989 Nov 24

PMID : 2512674






2 Functional Relationships(s)
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1 In contrast, thrombin-degranulated platelets released additional amounts of thromboxane in response to arachidonate, or collagen, indicating that short-time exposure to thrombin does not irreversibly inactivate platelet cyclooxygenase or thromboxane synthetase. Arachidonic Acid coagulation factor II, thrombin Homo sapiens
2 Incubation of platelets in plasma in the presence of added arachidonate for 90 min resulted in complete refractoriness to a second stimulation with thrombin but not with collagen. Arachidonic Acid coagulation factor II, thrombin Homo sapiens