Pub. Date : 2014 Sep 20
PMID : 25125004
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Testosterone-treated fibroblasts had decreased phosphorylated Akt, mammalian target of rapamycin, and 4E binding protein-1 irrespective of TGF-beta1 treatment and had increased matrix metalloproteinase (MMP)-2 in the presence of TGF-beta1 treatment, and had decreased phosphorylated P38 and Smad 2/3 levels in the presence of Ang II. | Testosterone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Cardiac fibroblasts with and without testosterone had similar mRNA and protein expressions of total Akt and total Smad 2/3 irrespective of TGF-beta1 or Ang II treatment. | Testosterone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | CONCLUSION: Physiological level of testosterone attenuated Akt and Smad 2/3 phosphorylation mediated by TGF-beta1 and angiotensin II respectively, which can result in decreased cardiac fibroblast activation and potentially contribute to beneficial effects in heart failure. | Testosterone | AKT serine/threonine kinase 1 | Homo sapiens |