Title : Androgen attenuates cardiac fibroblasts activations through modulations of transforming growth factor-β and angiotensin II signaling.

Pub. Date : 2014 Sep 20

PMID : 25125004






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1 CONCLUSION: Physiological level of testosterone attenuated Akt and Smad 2/3 phosphorylation mediated by TGF-beta1 and angiotensin II respectively, which can result in decreased cardiac fibroblast activation and potentially contribute to beneficial effects in heart failure. Testosterone angiotensinogen Homo sapiens