Pub. Date : 2014 Aug 11
PMID : 25116684
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin-Induced apoptosis in HGF-stimulated lens epithelial cells by AKT/mTOR, ERK and JAK2/STAT3 pathways. | Sirolimus | hepatocyte growth factor | Homo sapiens |
| 2 | The purpose of our study was to investigate the potential effects of rapamycin on HGF-induced LECs and the underlying mechanisms by which rapamycin exerted its actions. | Sirolimus | hepatocyte growth factor | Homo sapiens |
| 3 | The purpose of our study was to investigate the potential effects of rapamycin on HGF-induced LECs and the underlying mechanisms by which rapamycin exerted its actions. | Sirolimus | hepatocyte growth factor | Homo sapiens |
| 4 | Further investigation of the underlying mechanism using siRNA transfection revealed that rapamycin could promote apoptosis of LECs via inhibiting HGF-induced phosphorylation of AKT/mTOR, ERK and JAK2/STAT3 signaling molecules. | Sirolimus | hepatocyte growth factor | Homo sapiens |
| 5 | Together, these findings suggested that rapamycin-induced apoptosis in HGF-stimulated LECs is accompanied by inhibition of AKT/mTOR, ERK and JAK2/STAT3 pathways, which supports its use to inhibit PCO in preclinical studies and provides theoretical foundation for future possible practice. | Sirolimus | hepatocyte growth factor | Homo sapiens |