Pub. Date : 2014
PMID : 25116350
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Up-regulation of P21 inhibits TRAIL-mediated extrinsic apoptosis, contributing resistance to SAHA in acute myeloid leukemia cells. | Vorinostat | H3 histone pseudogene 16 | Homo sapiens |
| 2 | In this study we examined the effect of altered p21 expression on the sensitivity of acute myeloid leukemia cells in response to HDAC inhibitor SAHA treatment and investigated the underlying mechanism. | Vorinostat | H3 histone pseudogene 16 | Homo sapiens |
| 3 | Enforced expression of p21 in HL60 cells reduced sensitivity to SAHA and blocked TRAIL-mediated apoptosis. | Vorinostat | H3 histone pseudogene 16 | Homo sapiens |
| 4 | Conversely, p21 silencing in NB4 cells enhanced SAHA-mediated apoptosis and lethality. | Vorinostat | H3 histone pseudogene 16 | Homo sapiens |
| 5 | Finally, we found that combined treatment with SAHA and rapamycin down-regulated p21 and enhanced apoptosis in AML cells. | Vorinostat | H3 histone pseudogene 16 | Homo sapiens |
| 6 | CONCLUSION: We conclude that up-regulated p21 expression mediates resistance to SAHA via inhibition of TRAIL apoptotic pathway. | Vorinostat | H3 histone pseudogene 16 | Homo sapiens |
| 7 | P21 may serve as a candidate biomarker to predict responsiveness or resistance to SAHA-based therapy in AML patients. | Vorinostat | H3 histone pseudogene 16 | Homo sapiens |
| 8 | In addition, rapamycin may be an effective agent to override p21-mediated resistance to SAHA in AML patients. | Vorinostat | H3 histone pseudogene 16 | Homo sapiens |