Pub. Date : 2014 Sep 30
PMID : 25115399
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that cytoplasmic p53 suppresses cell invasion by reducing mitochondrial reactive oxygen species (ROS) levels. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | Here, we show that cytoplasmic p53 suppresses cell invasion by reducing mitochondrial reactive oxygen species (ROS) levels. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | Analysis revealed that this function is mediated by Bcl-2 family proteins: Cytoplasmic p53 binds Bcl-w, liberating Bax, which then binds ND5, a subunit of respiratory complex-I, thereby suppressing complex-I activity and thus ROS production. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | This study demonstrates a link between p53 and Bcl-2 proteins as regulators of ROS production and cellular invasiveness, and reveals complex-I, especially ND5, as their functional target. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |