Title : Free radical derivatives formed from cyclooxygenase-catalyzed dihomo-γ-linolenic acid peroxidation can attenuate colon cancer cell growth and enhance 5-fluorouracil's cytotoxicity.

Pub. Date : 2014

PMID : 25114837






1 Functional Relationships(s)
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1 Our study shows that the exclusive DGLA s free radical derivatives from C-8 oxygenation lead to cell growth inhibition, cell cycle arrest and apoptosis in the human colon cancer cell line HCA-7 colony 29, probably by up-regulating the cancer suppressor p53 and the cell cycle inhibitor p27. 8,11,14-Eicosatrienoic Acid tumor protein p53 Homo sapiens