Title : A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation.

Pub. Date : 1989 Dec

PMID : 2511437






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The 115-base pair (bp) region from -225 to -111 in the IL-6 5"-flanking region, which shares nucleotide sequence similarity with the c-fos serum response (SRE) and adjacent AP-1-like (the CGTCA motif) elements, confers responsiveness to several reagents, including serum, forskolin, and phorbol ester, upon the heterologous herpesvirus thymidine kinase (TK) promoter. Colforsin interleukin 6 Homo sapiens
2 Mutations in the AP-1-like site within AR1 (CGTCA----GTTCA) decreased inducibility of the chimeric IL-6/TK/chloramphenicol acetyltransferase gene by phorbol ester and by forskolin but not by serum, IL-1 alpha, or tumor necrosis factor. Colforsin interleukin 6 Homo sapiens