Title : Proline biosynthesis is required for endoplasmic reticulum stress tolerance in Saccharomyces cerevisiae.

Pub. Date : 2014 Oct 3

PMID : 25112878






2 Functional Relationships(s)
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1 To address this we examined in Saccharomyces cerevisiae the effect of knocking out the PRO1, PRO2, and PRO3 genes responsible for proline biosynthesis. Proline glutamate 5-kinase Saccharomyces cerevisiae S288C
2 The null mutants pro1, pro2, and pro3 were shown to have increased sensitivity to ER stress relative to wild-type cells, which could be restored by proline or the corresponding genetic complementation. Proline glutamate 5-kinase Saccharomyces cerevisiae S288C