Pub. Date : 2014 Nov
PMID : 25107562
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The rescuable function and mechanism of resveratrol on As2O3-induced hERG K+ channel deficiency. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 2 | Previous studies showed that As2O3 can damage the human ether-a-go-go-related gene (hERG) current via disturbing its trafficking to cellular membrane. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 3 | Further experiments demonstrate that resveratrol relieved As2O3-caused endoplasmic reticulum (ER) stress by restoring the function of hERG-Hsp70/Hsp90 chaperone complexes and downregulating the protein expression of ER chaperone proteins (calnexin and calreticulin) and activating transcription factor 6. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |