Title : The rescuable function and mechanism of resveratrol on As₂O₃-induced hERG K⁺ channel deficiency.

Pub. Date : 2014 Nov

PMID : 25107562






3 Functional Relationships(s)
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1 The rescuable function and mechanism of resveratrol on As2O3-induced hERG K+ channel deficiency. Arsenic Trioxide ETS transcription factor ERG Homo sapiens
2 Previous studies showed that As2O3 can damage the human ether-a-go-go-related gene (hERG) current via disturbing its trafficking to cellular membrane. Arsenic Trioxide ETS transcription factor ERG Homo sapiens
3 Further experiments demonstrate that resveratrol relieved As2O3-caused endoplasmic reticulum (ER) stress by restoring the function of hERG-Hsp70/Hsp90 chaperone complexes and downregulating the protein expression of ER chaperone proteins (calnexin and calreticulin) and activating transcription factor 6. Arsenic Trioxide ETS transcription factor ERG Homo sapiens