Pub. Date : 2015 Apr 15
PMID : 25107281
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Null mutation of the beta2 nicotinic acetylcholine receptor subunit attenuates nicotine withdrawal-induced anhedonia in mice. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 2 | Mecamylamine (6 mg/kg, salt) significantly elevated brain reward thresholds in nicotine-treated beta2(+/+) mice compared with saline-treated beta2(+/+) mice and nicotine-treated beta2(-/-) mice. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 3 | Spontaneous nicotine withdrawal similarly resulted in significant elevations in thresholds in nicotine-withdrawing beta2(+/+) mice compared with saline-treated beta2(+/+) and nicotine-treated beta2(-/-) mice, which remained at baseline levels. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 4 | Spontaneous nicotine withdrawal similarly resulted in significant elevations in thresholds in nicotine-withdrawing beta2(+/+) mice compared with saline-treated beta2(+/+) and nicotine-treated beta2(-/-) mice, which remained at baseline levels. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 5 | Spontaneous nicotine withdrawal similarly resulted in significant elevations in thresholds in nicotine-withdrawing beta2(+/+) mice compared with saline-treated beta2(+/+) and nicotine-treated beta2(-/-) mice, which remained at baseline levels. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 6 | These results showed that precipitated and spontaneous nicotine withdrawal-induced anhedonia was attenuated in beta2(-/-) mice. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 7 | The reduced expression of anhedonic signs during nicotine withdrawal in beta2(-/-) mice may have resulted from the lack of neuroadaptations in beta2 nACh receptor subunit expression and function that may have occurred during either nicotine exposure or nicotine withdrawal in wildtype mice. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |
| 8 | In conclusion, individuals with genetic variations that result in diminished function of the beta2 nACh receptor subunit may experience less anhedonia during nicotine withdrawal, which may facilitate smoking cessation. | Nicotine | hemoglobin, beta adult minor chain | Mus musculus |