Pub. Date : 2014 Sep
PMID : 25103325
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Physiologically based pharmacokinetic modeling of impaired carboxylesterase-1 activity: effects on oseltamivir disposition. | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 2 | METHODS: The antiviral drug oseltamivir, an ethyl ester prodrug that is rapidly converted in vivo to the active metabolite oseltamivir carboxylate (OSC) by CES1 was used as a probe drug for CES1 activity. | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 3 | METHODS: The antiviral drug oseltamivir, an ethyl ester prodrug that is rapidly converted in vivo to the active metabolite oseltamivir carboxylate (OSC) by CES1 was used as a probe drug for CES1 activity. | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 4 | Then the changes in oseltamivir and OSC exposure in humans with CES1 impaired by ethanol or polymorphisms were simulated using a PBPK model incorporating in vitro inhibition and enzyme kinetic data. | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 5 | RESULTS: The simulated changes in oseltamivir and OSC exposures in humans with CES1 impaired by ethanol or polymorphism were similar to the observed data. | Oseltamivir | carboxylesterase 1 | Homo sapiens |