Title : 5-Aminosalicylic acid attenuates allergen-induced airway inflammation and oxidative stress in asthma.

Pub. Date : 2014 Dec

PMID : 25101553






3 Functional Relationships(s)
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1 In the present study 5-aminosalicylic acid (5-ASA), a salicylic acid derivative, was evaluated, in vivo for its potential to suppress TNF-alpha, IL-6 and IL-13 using ovalbumin (OVA) induced allergic asthma in Balb/C mice. Mesalamine interleukin 6 Mus musculus
2 In the present study 5-aminosalicylic acid (5-ASA), a salicylic acid derivative, was evaluated, in vivo for its potential to suppress TNF-alpha, IL-6 and IL-13 using ovalbumin (OVA) induced allergic asthma in Balb/C mice. Mesalamine interleukin 6 Mus musculus
3 Oral administration of 65, 130 and 195 mg/kg 5-ASA significantly reduced the OVA induced total and differential leucocyte count, TNF-alpha, IL-6, IL-13, nitrite, nitrate, MDA, MPO and TPL levels in the lung lavage samples. Mesalamine interleukin 6 Mus musculus