Pub. Date : 2014
PMID : 25101238
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of GLUT1 in regulation of reactive oxygen species. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 2 | We hypothesized that conditions that would decrease GLUT1-mediated transport would cause increased reactive oxygen species (ROS) levels in L6 myoblasts, while conditions that would increase GLUT1-mediated transport would result in decreased ROS levels. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 3 | We hypothesized that conditions that would decrease GLUT1-mediated transport would cause increased reactive oxygen species (ROS) levels in L6 myoblasts, while conditions that would increase GLUT1-mediated transport would result in decreased ROS levels. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 4 | We found that the GLUT1 inhibitors fasentin and phloretin increased the ROS levels induced by antimycin A and the superoxide generator pyrogallol. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 5 | Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 6 | Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 7 | Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 8 | Mutation of an ATM target site on GLUT1 (GLUT1-S490A) increased ROS levels and prevented the ROS-lowering effect of the ATM activator doxorubicin. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 9 | In contrast, expression of GLUT1-S490D lowered ROS levels during challenge with pyrogallol, prevented an increase in ROS when ATM was inhibited, and prevented the pyrogallol-induced decrease in insulin signaling and insulin-stimulated glucose transport. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 10 | In contrast, expression of GLUT1-S490D lowered ROS levels during challenge with pyrogallol, prevented an increase in ROS when ATM was inhibited, and prevented the pyrogallol-induced decrease in insulin signaling and insulin-stimulated glucose transport. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 11 | Taken together, the data suggest that GLUT1 plays a role in regulation of ROS and could contribute to maintenance of insulin action in the presence of ROS. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |
| 12 | Taken together, the data suggest that GLUT1 plays a role in regulation of ROS and could contribute to maintenance of insulin action in the presence of ROS. | Reactive Oxygen Species | solute carrier family 2 member 1 | Homo sapiens |