Title : Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.

Pub. Date : 2014 Aug 5

PMID : 25097034






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The Itk PH domain bound synergistically to Ca(2+)/CaM and the lipid phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3], such that binding to Ca(2+)/CaM enhanced the binding to PI(3,4,5)P3 and vice versa. phosphoinositide-3,4,5-triphosphate calmodulin 1 Homo sapiens
2 The Itk PH domain bound synergistically to Ca(2+)/CaM and the lipid phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3], such that binding to Ca(2+)/CaM enhanced the binding to PI(3,4,5)P3 and vice versa. phosphoinositide-3,4,5-triphosphate calmodulin 1 Homo sapiens
3 The Itk PH domain bound synergistically to Ca(2+)/CaM and the lipid phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3], such that binding to Ca(2+)/CaM enhanced the binding to PI(3,4,5)P3 and vice versa. phosphoinositide-3,4,5-triphosphate calmodulin 1 Homo sapiens