Title : Altered thiol chemistry in human amyotrophic lateral sclerosis-linked mutants of superoxide dismutase 1.

Pub. Date : 2014 Sep 26

PMID : 25096579






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Altered thiol chemistry in human amyotrophic lateral sclerosis-linked mutants of superoxide dismutase 1. Sulfhydryl Compounds superoxide dismutase 1 Homo sapiens
2 In human SOD1 (hSOD1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfide exchange resulting in non-native disulfides, a hallmark of ALS that is related to protein misfolding and aggregation. Sulfhydryl Compounds superoxide dismutase 1 Homo sapiens
3 In human SOD1 (hSOD1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfide exchange resulting in non-native disulfides, a hallmark of ALS that is related to protein misfolding and aggregation. Sulfhydryl Compounds superoxide dismutase 1 Homo sapiens