Title : Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.

Pub. Date : 2014 Sep 1

PMID : 25091930






1 Functional Relationships(s)
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1 The potency of the carboxylate series is now further improved through structure-based optimization of ligand-protein interactions in the proline binding site which exploits the H-bond interactions necessary for Pin1 catalytic function. Proline peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens