Title : Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase.

Pub. Date : 2014 Sep 1

PMID : 25088549






2 Functional Relationships(s)
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1 Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Abeta aggregation, and beta-secretase. coumarin acetylcholinesterase (Cartwright blood group) Homo sapiens
2 In present study, a series of novel tacrine-coumarin hybrids were designed, synthesized and evaluated as potent dual-site AChE inhibitors. coumarin acetylcholinesterase (Cartwright blood group) Homo sapiens