Title : TCF2 attenuates FFA-induced damage in islet β-cells by regulating production of insulin and ROS.

Pub. Date : 2014 Jul 30

PMID : 25079440






3 Functional Relationships(s)
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Protein Name
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1 In addition, both PI3K/AKT and MEK/ERK showed decreased expression in PA (800 muM)-treated beta-cells. Palmitic Acid AKT serine/threonine kinase 1 Homo sapiens
2 Overexpression of TCF2 could effectively restore the inhibitory effect of PA on the activation of PI3K/AKT and MEK/ERK as well as beta-cell viability, simultaneously, inhibited PA-induced reactive oxygen species (ROS) generation. Palmitic Acid AKT serine/threonine kinase 1 Homo sapiens
3 Overexpression of TCF2 could effectively restore the inhibitory effect of PA on the activation of PI3K/AKT and MEK/ERK as well as beta-cell viability, simultaneously, inhibited PA-induced reactive oxygen species (ROS) generation. Palmitic Acid AKT serine/threonine kinase 1 Homo sapiens