Pub. Date : 2014 Sep
PMID : 25079084
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice. | Oleanolic Acid | brain derived neurotrophic factor | Mus musculus |
| 2 | BACKGROUND: Although previous study has demonstrated that brain-derived neurotrophic factor (BDNF) is involved in the antidepressant-like effect of oleanolic acid, there is little information regarding the details of the molecular mechanism involved in this effect. | Oleanolic Acid | brain derived neurotrophic factor | Mus musculus |
| 3 | BACKGROUND: Although previous study has demonstrated that brain-derived neurotrophic factor (BDNF) is involved in the antidepressant-like effect of oleanolic acid, there is little information regarding the details of the molecular mechanism involved in this effect. | Oleanolic Acid | brain derived neurotrophic factor | Mus musculus |
| 4 | Furthermore, we found that oleanolic acid led to the BDNF-related phosphorylation and activation of extracellular signal-regulated kinases (ERK) and cyclic adenosine monophosphate response element binding protein (CREB), which was associated with the upregulation of miR-132 and hippocampal neuronal proliferation. | Oleanolic Acid | brain derived neurotrophic factor | Mus musculus |
| 5 | CONCLUSION: Our results show that oleanolic acid induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways. | Oleanolic Acid | brain derived neurotrophic factor | Mus musculus |