Pub. Date : 2014 Sep
PMID : 25074866
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Association of MDR1 C3435T and RFC1 G80A polymorphisms with methotrexate toxicity and response in Jordanian rheumatoid arthritis patients. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Genetic polymorphisms of reduced folate carrier (RFC1 G80A) and multi-drug resistance-1 (MDR1 C3435T) might affect MTX response and/or toxicity. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Genetic polymorphisms of reduced folate carrier (RFC1 G80A) and multi-drug resistance-1 (MDR1 C3435T) might affect MTX response and/or toxicity. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | RESULTS: There was an association between RFC1 G80A and MDR1 C3435T polymorphisms with MTX toxicity. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Patients carrying at least one MDR1 3435T variant allele were at higher risk for MTX overall toxicity (p = 0.04), especially hepatotoxicity (p = 0.028). | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |