Title : Interleukin-1 potentiates bradykinin- and TNF alpha-induced PGE2 release.

Pub. Date : 1989 Jul 18

PMID : 2507329






3 Functional Relationships(s)
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1 When the cells were pretreated with IL-1 alpha or IL-1 beta for 24 h, their ability to release PGE2 in response to a short incubation (1 h) with bradykinin, TNF alpha or a second dose of IL-1 was potentiated. Dinoprostone interleukin 1 beta Homo sapiens
2 When the cells were pretreated with IL-1 alpha or IL-1 beta for 24 h, their ability to release PGE2 in response to a short incubation (1 h) with bradykinin, TNF alpha or a second dose of IL-1 was potentiated. Dinoprostone interleukin 1 beta Homo sapiens
3 It seems likely, therefore, that activation of phospholipase A2 which occurs during a short incubation with IL-1, TNF alpha or bradykinin releases substrate, AA, which is more rapidly converted to PGE2 by cells in which CO has been induced. Dinoprostone interleukin 1 beta Homo sapiens