Pub. Date : 2014 Oct
PMID : 25064633
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage. | Curcumin | C-C motif chemokine ligand 2 | Homo sapiens |
2 | OBJECTIVE: To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved. | Curcumin | C-C motif chemokine ligand 2 | Homo sapiens |
3 | OBJECTIVE: To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved. | Curcumin | C-C motif chemokine ligand 2 | Homo sapiens |
4 | RESULTS: Curcumin decreased the production of MCP-1 induced by ox-LDL in macrophages. | Curcumin | C-C motif chemokine ligand 2 | Homo sapiens |
5 | CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis. | Curcumin | C-C motif chemokine ligand 2 | Homo sapiens |