Title : Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage.

Pub. Date : 2014 Oct

PMID : 25064633






5 Functional Relationships(s)
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1 Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage. Curcumin C-C motif chemokine ligand 2 Homo sapiens
2 OBJECTIVE: To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved. Curcumin C-C motif chemokine ligand 2 Homo sapiens
3 OBJECTIVE: To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved. Curcumin C-C motif chemokine ligand 2 Homo sapiens
4 RESULTS: Curcumin decreased the production of MCP-1 induced by ox-LDL in macrophages. Curcumin C-C motif chemokine ligand 2 Homo sapiens
5 CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis. Curcumin C-C motif chemokine ligand 2 Homo sapiens