Pub. Date : 2014 Oct
PMID : 25061110
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions. | Hydrogen Peroxide | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | In the presence of redox active transition metals, H2O2 can form highly toxic hydroxyl radicals and, depending on the "oxidase" activity of individual cytochrome P450 isoenzymes, this can compromise cellular functioning and contribute to tissue injury. | Hydrogen Peroxide | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | Significantly greater activity was detected in preparations containing individual cytochrome P450s coexpressed with CPR (from 6.0 nmol H2O2/min/nmol P450 to 0.2 nmol/min/nmol P450); CYP1A1 was the most active, followed by CYP2D6, CYP3A4, CYP2E1, CYP4A11, CYP1A2, and CYP2C subfamily enzymes. | Hydrogen Peroxide | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 4 | H2O2 generating activity of the cytochrome P450s was independent of the ratio of CYP/CPR. | Hydrogen Peroxide | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 5 | Because CYP3A4/5/7 represent up to 40% of total cytochrome P450 in the liver, these data indicate that these enzymes are the major source of H2O2 in human liver microsomes. | Hydrogen Peroxide | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |