Pub. Date : 2014 Dec
PMID : 25043721
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Contribution of sodium channels to lamellipodial protrusion and Rac1 and ERK1/2 activation in ATP-stimulated microglia. | Adenosine Triphosphate | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Here we show that TTX-sensitive sodium channels, specifically NaV 1.6, participate in an initial event in the migratory process, i.e., the formation in ATP-stimulated microglia of polymerized actin-rich membrane protrusions, lamellipodia, containing accumulations of Rac1 and phosphorylated ERK1/2. | Adenosine Triphosphate | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Consistent with these observations, we demonstrate that ATP-induced microglial migration is mediated via Rac1 and ERK1/2, but not p38alpha/beta and JNK, dependent pathways, and that activation of both Rac1 and ERK1/2 is modulated by sodium channel activity. | Adenosine Triphosphate | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | Consistent with these observations, we demonstrate that ATP-induced microglial migration is mediated via Rac1 and ERK1/2, but not p38alpha/beta and JNK, dependent pathways, and that activation of both Rac1 and ERK1/2 is modulated by sodium channel activity. | Adenosine Triphosphate | mitogen-activated protein kinase 3 | Homo sapiens |
| 5 | Our results provide evidence for a direct link between sodium channel activity and modulation of Rac1 and ERK1/2 activation in ATP-stimulated microglia, possibly by regulating Ca(2+) transients. | Adenosine Triphosphate | mitogen-activated protein kinase 3 | Homo sapiens |