Title : Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases.

Pub. Date : 2014 Dec

PMID : 25043383






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Diphenyleneiodonium (DPI) is a widely used, long-acting NOX2 inhibitor. diphenyleneiodonium cytochrome b-245 beta chain Homo sapiens
2 Diphenyleneiodonium (DPI) is a widely used, long-acting NOX2 inhibitor. diphenyleneiodonium cytochrome b-245 beta chain Homo sapiens
3 In this study, using ultra-low doses of DPI, we aimed to: (1) investigate whether these problems could be circumvented and (2) determine whether ultra-low doses of DPI were able to preserve its utility as a potent NOX2 inhibitor. diphenyleneiodonium cytochrome b-245 beta chain Homo sapiens
4 More importantly, we observed that subpicomolar DPI inhibited phorbol myristate acetate (PMA)-induced activation of NOX2. diphenyleneiodonium cytochrome b-245 beta chain Homo sapiens
5 In summary, DPI"s unique combination of high specificity toward NOX2, low cytotoxicity and potent neuroprotective efficacy in post-treatment regimens suggests that subpicomolar DPI may be an ideal candidate for further animal studies and potential clinical trials. diphenyleneiodonium cytochrome b-245 beta chain Homo sapiens