Title : Leptin inhibits amyloid β-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway.

Pub. Date : 2014 Nov

PMID : 25039425






2 Functional Relationships(s)
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1 The increase in GM1 expression induced by leptin was inhibited after pre-treatment with inhibitors of phosphatidylinositol 3-kinase (LY294002), Akt (triciribine) and the mammalian target of rapamycin (i.e. rapamycin), but not by an inhibitor of extracellular signal-regulated kinase (PD98059). G(M1) Ganglioside AKT serine/threonine kinase 1 Homo sapiens
2 These results suggest that leptin significantly inhibits Abeta assembly by decreasing GM1 expression in DRMs of the neuronal surface through the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway. G(M1) Ganglioside AKT serine/threonine kinase 1 Homo sapiens