Title : Novel Cu(I)-selective chelators based on a bis(phosphorothioyl)amide scaffold.

Pub. Date : 2014 Aug 4

PMID : 25033439






2 Functional Relationships(s)
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1 In Cu(I)-H2O2 system (Fenton reaction conditions) BTPA compounds 6, 8, and 10 (NCH2Ph) were identified as most potent antioxidants (IC50 32, 56, and 29 muM, respectively), whereas BOPA analogues 7, 9 (NEt), and 11 (NCH2Ph) were found to be poor antioxidants. Hydrogen Peroxide latexin Homo sapiens
2 In Fe(II)-H2O2 system, IC50 values for both BTPA and BOPA compounds exceeded 500 muM indicating high selectivity to Cu(I) versus the borderline Fe(II)-ion. Hydrogen Peroxide latexin Homo sapiens