Title : 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 11. Quinolylmethyl analogues with basic substituents conveying specificity.

Pub. Date : 1989 Aug

PMID : 2502633






1 Functional Relationships(s)
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1 Those compounds that had basic substituents in the 2-position of the quinoline ring were also highly specific for bacterial dihydrofolate DHFR, relative to a vertebrate counterpart. dihydrofolate Dihydrofolate reductase Escherichia coli