Pub. Date : 2014 Dec
PMID : 25023940
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Piperlongumine induces cell death through ROS-mediated CHOP activation and potentiates TRAIL-induced cell death in breast cancer cells. | Reactive Oxygen Species | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | Pretreatment with the ROS scavenger N-acetyl-cysteine abolishes the PL-induced up-regulation of CHOP and its target genes, suggesting an essential role for ROS in PL-induced CHOP activation. | Reactive Oxygen Species | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | Pretreatment with the ROS scavenger N-acetyl-cysteine abolishes the PL-induced up-regulation of CHOP and its target genes, suggesting an essential role for ROS in PL-induced CHOP activation. | Reactive Oxygen Species | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | Pretreatment with the ROS scavenger N-acetyl-cysteine abolishes the PL-induced up-regulation of CHOP and its target genes, suggesting an essential role for ROS in PL-induced CHOP activation. | Reactive Oxygen Species | DNA damage inducible transcript 3 | Homo sapiens |
| 5 | Pretreatment with the ROS scavenger N-acetyl-cysteine abolishes the PL-induced up-regulation of CHOP and its target genes, suggesting an essential role for ROS in PL-induced CHOP activation. | Reactive Oxygen Species | DNA damage inducible transcript 3 | Homo sapiens |
| 6 | CONCLUSIONS: Overall, our data suggest a new mechanism for the PL-induced cell death in which ROS mediates CHOP activation, and combination treatment with PL and TRAIL could be a potential strategy for breast cancer therapy. | Reactive Oxygen Species | DNA damage inducible transcript 3 | Homo sapiens |