Title : ERK1/2 mediates sperm acrosome reaction through elevation of intracellular calcium concentration.

Pub. Date : 2015 Oct

PMID : 25023718






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The mitogen-activated ERK-kinase (MEK) inhibitor U0126 abolished ERK1/2 phosphorylation, in vitro fertilization rate and the acrosome reaction induced by ZP or EGF but not by the Ca2+-ionophore A23187. U 0126 epidermal growth factor Homo sapiens
2 Direct determination of intracellular [Ca2+] revealed that Ca2+ influx induced by EGF or ZP was completely blocked by U0126. U 0126 epidermal growth factor Homo sapiens