Title : Modulation of endotoxicity of Shigella generalized modules for membrane antigens (GMMA) by genetic lipid A modifications: relative activation of TLR4 and TLR2 pathways in different mutants.

Pub. Date : 2014 Sep 5

PMID : 25023285






1 Functional Relationships(s)
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1 In contrast, in the S. flexneri DeltahtrB mutant, a compensatory lipid A palmitoleoylation resulted in GMMA with hexa-acylated lipid A with ~10-fold higher activity to stimulate peripheral blood mononuclear cells than GMMA with penta-acylated lipid A, mostly due to retained TLR4 activity. Lipid A toll like receptor 4 Homo sapiens