Title : Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: II. Role of human ZIP9 in testosterone-induced prostate and breast cancer cell apoptosis.

Pub. Date : 2014 Nov

PMID : 25014355






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Testosterone treatment caused up-regulation of proapoptotic genes Bax (Bcl-2-associated X protein), p53 (tumor protein p53), and JNK (c-Jun N-terminal kinases) in both cell lines and increased expression of Bax, Caspase 3, and cytochrome C proteins. Testosterone mitogen-activated protein kinase 8 Homo sapiens
2 Testosterone treatment caused up-regulation of proapoptotic genes Bax (Bcl-2-associated X protein), p53 (tumor protein p53), and JNK (c-Jun N-terminal kinases) in both cell lines and increased expression of Bax, Caspase 3, and cytochrome C proteins. Testosterone mitogen-activated protein kinase 8 Homo sapiens
3 Treatment with a zinc chelator or a MAPK inhibitor blocked testosterone-induced increases in Bax, p53, and JNK mRNA expression. Testosterone mitogen-activated protein kinase 8 Homo sapiens