Title : Functional and biochemical interaction between PPARα receptors and TRPV1 channels: Potential role in PPARα agonists-mediated analgesia.

Pub. Date : 2014 Sep

PMID : 25014183






1 Functional Relationships(s)
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1 In TRPV1-expressing CHO cells, patch-clamp studies revealed that acute application of the PPARalpha agonists clofibrate (CLO; 0.1-100 muM), WY14643 (1-300 muM), or GW7647 (0.1-100 nM) activated TRPV1 currents in a concentration-dependent manner, with EC50s of 5.3 +- 0.8 muM, 13.0 +- 1.2 muM, and 12.7 +- 0.3 nM, respectively. CAV protocol peroxisome proliferator-activated receptor alpha Cricetulus griseus