Title : Comparison of Intracellular Stress Response of NCI-H526 Small Cell Lung Cancer (SCLC) Cells to Platinum(II) Cisplatin and Platinum(IV) Oxoplatin.

Pub. Date : 2014 Jul 8

PMID : 25006835






1 Functional Relationships(s)
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1 Cisplatin induced hyperphosphorylation of p38alpha MAPK and AMPKalpha1, whereas oxoplatin treatment resulted in increased phosphorylation of a large number of signaling proteins involved in stress response/drug resistance, including JNK, GSK-3alpha, AMPKalpha1, src kinases, STATs, CHK-2 and especially focal adhesion kinase (FAK). Cisplatin checkpoint kinase 2 Homo sapiens