Pub. Date : 2014 Jun 15
PMID : 25004403
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting Phosphatidylinositide3-Kinase/Akt pathway by BKM120 for radiosensitization in hepatocellular carcinoma. | NVP-BKM120 | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Our aim was to determine whether the inhibition of PI3K/Akt activity by a PI3K inhibitor, BKM120, contributes to the increased sensitivity of liver cancer cells to irradiation. | NVP-BKM120 | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | BKM120 pretreatment inhibited radiation-induced Akt phosphorylation and enhanced the tumor-suppressive effect and radiation-induced tumor cell apoptosis in ectopic xenografts. | NVP-BKM120 | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | The synergism between BKM120 and irradiation likely inhibits the activation of Akt by radiation, leading to increased cell apoptosis and suppression of DNA-double-strand breaks repair in hepatocellular carcinoma cells. | NVP-BKM120 | thymoma viral proto-oncogene 1 | Mus musculus |