Title : Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D development.

Pub. Date : 2014 Sep

PMID : 25004092






1 Functional Relationships(s)
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1 We find that the proinflammatory cytokine combination IL-1beta+IFNgamma, induces: a) ER stress, mSREBP-1, and iPLA2beta, b) lysophosphatidylcholine (LPC) generation, c) neutral sphingomyelinase-2 (NSMase2), d) ceramide accumulation, e) mitochondrial membrane decompensation, f) caspase-3 activation, and g) beta-cell apoptosis. Lysophosphatidylcholines interleukin 1 beta Mus musculus