Title : Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells.

Pub. Date : 2014 Aug 26

PMID : 25003661






2 Functional Relationships(s)
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1 RESULTS: ATO induced an antioxidant response characterised by Nrf2 nuclear translocation and enhanced transcription of downstream target genes (that is, HO-1, NQO1, GCLM, ferritin). Arsenic Trioxide NFE2 like bZIP transcription factor 2 Homo sapiens
2 In cells exposed to ATO plus ATRA, the Nrf2 nuclear translocation was prevented and cytotoxicity was enhanced. Arsenic Trioxide NFE2 like bZIP transcription factor 2 Homo sapiens