Title : Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.

Pub. Date : 2014 Jul 14

PMID : 25002027






1 Functional Relationships(s)
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1 The mechanism involves the regulation of cellular redox through an mTORC1/c-Myc pathway of stromal glucose and amino acid metabolism, resulting in increased stromal IL-6 production, which is required for tumor promotion in the epithelial compartment. Glucose interleukin 6 Homo sapiens