Pub. Date : 2014
PMID : 25000190
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-kappaB/p300 signaling pathways. | fisetin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Thus, these results demonstrated that melatonin potentiated the anti-tumor effect of fisetin in melanoma cells by activating cytochrome-c-dependent apoptotic pathway and inhibiting COX-2/iNOS and NF-kappaB/p300 signaling pathways, and our study suggests the potential of such a combinational treatment of natural products in melanoma therapy. | fisetin | nuclear factor kappa B subunit 1 | Homo sapiens |