Title : Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways.

Pub. Date : 2014

PMID : 25000190






2 Functional Relationships(s)
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1 Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-kappaB/p300 signaling pathways. fisetin nuclear factor kappa B subunit 1 Homo sapiens
2 Thus, these results demonstrated that melatonin potentiated the anti-tumor effect of fisetin in melanoma cells by activating cytochrome-c-dependent apoptotic pathway and inhibiting COX-2/iNOS and NF-kappaB/p300 signaling pathways, and our study suggests the potential of such a combinational treatment of natural products in melanoma therapy. fisetin nuclear factor kappa B subunit 1 Homo sapiens