Pub. Date : 2014
PMID : 25000190
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-kappaB/p300 signaling pathways. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | The combinational treatment of fisetin with melatonin increased the cleavage of PARP proteins, triggered more release of cytochrome-c from the mitochondrial inter-membrane, enhanced the inhibition of COX-2 and iNOS expression, repressed the nuclear localization of p300 and NF-kappaB proteins, and abrogated the binding of NF-kappaB on COX-2 promoter. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | The combinational treatment of fisetin with melatonin increased the cleavage of PARP proteins, triggered more release of cytochrome-c from the mitochondrial inter-membrane, enhanced the inhibition of COX-2 and iNOS expression, repressed the nuclear localization of p300 and NF-kappaB proteins, and abrogated the binding of NF-kappaB on COX-2 promoter. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Thus, these results demonstrated that melatonin potentiated the anti-tumor effect of fisetin in melanoma cells by activating cytochrome-c-dependent apoptotic pathway and inhibiting COX-2/iNOS and NF-kappaB/p300 signaling pathways, and our study suggests the potential of such a combinational treatment of natural products in melanoma therapy. | Melatonin | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |