Title : Antiproliferative effects of celecoxib in Hep-2 cells through telomerase inhibition and induction of apoptosis.

Pub. Date : 2014

PMID : 24998564






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1 RESULTS: Celecoxib can inhibit proliferation and induce apoptosis in a dose- and time-dependent manner, repress telomerase activity, decrease hTERT mRNA and Bcl-2 protein expression and increase Bax protein expression, PGE2 had no effect on telomerase. Celecoxib BCL2 associated X, apoptosis regulator Homo sapiens