Pub. Date : 2014
PMID : 24995301
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The study was designed to determine the effects of peripheral injection of SB203580 on the synthesis of interleukin- (IL-) 1beta, IL-6, and tumor necrosis factor (TNF) alpha in the hypothalamus of ewes during prolonged inflammation. | SB 203580 | interleukin 6 | Homo sapiens |
| 2 | SB203580 is a selective ATP-competitive inhibitor of the p38 mitogen-activated protein kinase (MAPK), which is involved in the regulation of proinflammatory cytokines IL-1beta, IL-6 and TNFalpha synthesis. | SB 203580 | interleukin 6 | Homo sapiens |
| 3 | Intravenous injection of SB203580 successfully inhibited (P < 0.01) synthesis of IL-1beta and reduced (P < 0.01) the production of IL-6 in the hypothalamus. | SB 203580 | interleukin 6 | Homo sapiens |