Title : The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer.

Pub. Date : 2014

PMID : 24995161






2 Functional Relationships(s)
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1 AKR1C3 is a novel therapeutic target in castration-resistant prostate cancer (CRPC) and estrogen receptor (ER)-positive breast cancer because of its ability to produce testosterone and 17beta-estradiol intratumorally, thus promoting nuclear receptor signaling and tumor progression. Testosterone estrogen receptor 1 Homo sapiens
2 AKR1C3 is a novel therapeutic target in castration-resistant prostate cancer (CRPC) and estrogen receptor (ER)-positive breast cancer because of its ability to produce testosterone and 17beta-estradiol intratumorally, thus promoting nuclear receptor signaling and tumor progression. Testosterone estrogen receptor 1 Homo sapiens