Title : Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.

Pub. Date : 2014 Sep

PMID : 24994071






1 Functional Relationships(s)
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1 Ten prodrugs in the data set are predominantly hydrolyzed by carboxylesterases (CES), whereas olmesartan medoxomil is also metabolized by carboxymethylenebutenolidase (CMBL) and paraoxonase. olmesartan carboxymethylenebutenolidase homolog Homo sapiens