Pub. Date : 1989 Apr
PMID : 2498455
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rise of plasma t-PA fibrinolytic activity in a group of maturity onset diabetic patients shifted from a first generation (tolbutamide) to a second generation sulphonylurea (gliclazide). | Gliclazide | plasminogen activator, tissue type | Homo sapiens |
| 2 | All 10 patients responded on the change in treatment to gliclazide with an increase in activity of t-PA. | Gliclazide | plasminogen activator, tissue type | Homo sapiens |
| 3 | The concentration in plasma of t-PA antigen under basal conditions and after stimulation (venous occlusion) increased significantly during the period of treatment with gliclazide. | Gliclazide | plasminogen activator, tissue type | Homo sapiens |
| 4 | In contrast to these findings seven patients with marked activities of t-PA during treatment with tolbutamide retained unchanged levels of the variables reported above after a change in treatment to gliclazide. | Gliclazide | plasminogen activator, tissue type | Homo sapiens |