Title : Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.

Pub. Date : 2014 Aug 18

PMID : 24983538






1 Functional Relationships(s)
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1 The additional H-bonds with the oxygen of the amide and/or H of NH of the amide with the amino acid residues may be responsible for the higher binding affinity of this group of compounds towards COX-2. Oxygen mitochondrially encoded cytochrome c oxidase II Homo sapiens