Title : Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis.

Pub. Date : 2014 Aug

PMID : 24974736






1 Functional Relationships(s)
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1 Sunitinib or LY294002, but not erlotinib, significantly inhibited the platelet-induced proliferation of osteosarcoma cells, indicating that PDGF released from platelets plays an important role in the proliferation of osteosarcomas by activating the PDGFR and then Akt. Sunitinib AKT serine/threonine kinase 1 Homo sapiens